Dutch biotechnology company Annogen has entered into a collaboration with a Tier 1 agricultural company to research non-coding DNA influencing gene expression using Annogen’s SuRE technology. Through the research collaboration, both companies will work to identify non-coding DNA fragments in plant genomes that influence the expression of important crop traits. This is expected to open new opportunities to intentionally upregulate or downregulate the expression of important genes in crops. Tier 1 companies are generally the largest or the most technically capable companies in the supply chain. Annogen recently entered into a similar agreement with KeyGene (see AgbioNews Mar 18, 2021).