The European Food Safety Authority (EFSA) has reported a positive scientific opinion of Syngenta's genetically modified (GM) herbicide-tolerant and insect-resistant maize Bt11 × MIR162 × MIR604 × MON 89034 × 5307 × GA21 and 30 different sub-combinations for food and feed uses. The six-event stack maize was produced by conventional crossing to combine six single maize events:

• Bt11, expressing the Cry1Ab protein for protection against certain lepidopteran pests and the phosphinothricin acetyl transferase (PAT) protein for tolerance to glufosinate ammonium containing herbicides;
• MIR162, expressing the Vip3Aa20 protein against certain lepidopteran pests;
• MIR604, expressing a modified Cry3A (mCry3A) protein against certain coleopteran pests;
• MON 89034 expressing Cry1A.105 and Cry2Ab2 proteins against certain lepidopteran pests;
• Event 5307, expressing the eCry3.1Ab protein against certain coleopteran pests;
• GA21, expressing the 5-enolpyruvylshikimate-3-phosphate synthase enzyme (mEPSPS) protein for tolerance to glyphosate-containing herbicides.

The review, undertaken by the GMO Panel, concluded that the six-event stack maize and the 30 sub-combinations covered by the scope of the application are as safe as its conventional counterpart and the tested non-GM maize varieties with respect to potential effects on human and animal health and the environment.